Little Red Herrings — Patience and Fortitude

Red herrings and rotten fish

Geoffrey B. West ∗, Van M. Savage, James Gillooly, Brian J. Enquist, William. H. Woodruff, James H. Brown 1 Los Alamos National Laboratory, Los Alamos, NM 87545, USA. 2 The Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501, USA. 3 Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA. 4 Department of Ecology and Evolutionary Biology, University of Arizona, Tucson...

MEFV mutations - therapeutic guides or red herrings?

Background/question Familial Mediterranean Fever (FMF) is a hereditary inflammatory disorder characterised by self-resolving attacks of fever and serositis common in populations from Mediterranean ancestry [1]. Mutations affecting MEFV gene is believed to be responsible for the disease phenotype[1]. The correlation between the genotype and phenotype is not very strong, indicating the presence o...

Little patients, losing patience: pediatric cancer drug development.

The December 2004 Food and Drug Administration (FDA) approval of clofarabine (Clolar, Genzyme) for refractory pediatric acute lymphoblastic leukemia was a milestone in the history of pediatric cancer drug development. A rare occurrence, it represented approval of a new cancer drug for a pediatric cancer indication without prior approval for an adult cancer indication. This is a major exception,...

Have a Little Patience: Let Planners Play Cards

As every card player knows, most existing card games share a large number of actions and situations. This is the case, for instance, for stacking cards in columns according to some allowed sequence or taking cards from a deal. This is true for both multi-player and solitaire patience games. Although they have such strong similarities, every game also has some peculiarity making it different, an...

Chasing red herrings: making sense of the colors while mapping.